An important public health issue worldwide is preventing the transmission of infectious diseases by insect bites, such as mosquito bites. Throughout the years, the cases of mosquito-related diseases have not lowered. This may be because mosquitoes can reproduce quickly, and it only takes 8-10 days for a mosquito egg to become an adult.

There are different diseases that mosquitoes carry with them, and with just a bite, they can transmit it to a human. Some of the most common illnesses linked to these pesky insects are Dengue, Chikungunya, Malaria, and Zika. 

To prevent exposure to these diseases, you should perform precautionary measures like using repellents, cleaning surroundings, and wearing appropriate clothes. 

Currently, there is a large market for insect repellents and insect bite control products. These products may come in the form of sprays, patches, creams, sticks, wipes, or lotions. Through these repellents, you can highly prevent mosquito-borne diseases. An excellent example of these insect repellents is the IR-3535. 

Read on to learn more about IR-3535.

What Is IR-3535?

IR-3535, also known as Insect Repellent 3535, is a synthetic insect repellent initially developed in the 1980s by Merck. Many brands use IR-3535 in their products since it is an odorless molecule. With this benefit, most of the products that use this repellent have a pleasant smell.

If you are looking for a highly effective, DEET-free product to combat mosquitoes, ticks, and lice, then IR-3535 is the perfect choice for you. 

Using IR-3535 can provide long-term protection from mosquito-borne diseases. It can also let you have a quiet night after a busy day by swaying away insects that keep buzzing around you at night. 

How Does IR-3535 Work?

How Does IR-3535 Work?

Despite its imposing chemical name of Ethyl butyl acetyl propionate, IR3535 is only a simple amino acid that causes insects to lose their sense of smell. It is structurally similar to the natural substance, a beta-amino acid, a component of pantothenic acid (vitamin B5). 

Similar to when using other products, it is always best to read the directions of using a product to avoid harming yourself, your family, and your pets. Here, we have prepared a guide that you can use when using IR-3535.

  • Apply directly on the skin and leave it to dry. 
  • An application typically lasts 4-8 hours. Avoid applying it near your eyes or mouth, on wounds or irritated skin.
  • Although not believed to be toxic if ingested, you should still keep it away from food and food preparation areas and not apply it to children’s hands.
  • It has been used in Europe for over 30 years, where it has established an excellent safety record. The French Ministry of Health recommended it for use by pregnant women and children during a recent Chikungunya outbreak. It is one of the only four repellents recommended by the CDC for protection against mosquitoes carrying the Zika Virus.

Aside from protecting you, IR-3535 can also be used to protect your beloved pets such as dogs, cats, and horses.

No one wants to spend their time outdoors when mosquitoes are swarming around them. Visit Pest Guide today and consult with pest control professionals.

Consult With Pest Control Professionals

You should always take insect bites seriously. If your insect problem is becoming out of control, you need to consult with pest control professionals.

Visit Pest Guide for a free estimate.

You can also access our free resources, guides, and reviews of products to help you eradicate bugs from your home.


“If you are traveling to endemic areas and planning to engage in outdoor activities, make sure to take insect repellent with you.”

IR-3535 FAQs

Is it possible to apply IR-3535 directly onto my scalp to kill lice?

Yes. To protect yourself from lice, you need to apply IR-3535 directly on your scalp. This method may protect you from getting lice for 2 days, given that you won’t rinse it off with water. From previous research, using IR-3535 did not cause irritation, redness, or itching. 

Does IR-3535 work better than DEET?

Both repellents’ effectiveness is almost the same, but IR-3535 is safer to use since DEET has some toxic properties. Besides, IR-3535 is safe to use on pets, unlike DEET that may pose hazards to pets when accidentally licked.

Can I use insect repellent with IR-3535 on my baby?

Yes. Since a naturally occurring amino acid inspired IR-3535, it is tolerable for humans. Most insect repellents that use IR-3535 are safe for infants, pregnant women, and pets. Still, you should use insect repellents with caution and follow the directions found on the label.